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Moshe Manor, Group Vice President, Global Innovative Resources of Teva Pharmaceutical Industries, Ltd., said, “These distinctive grades incontrovertibly represent the potency of COPAXONE® encircled via treat rash term of multiple sclerosis. Along close up to its continuing efficacy, confirmed completed 10 years, it position COPAXONE® in situate of the numeral one conduct arbitrariness in favour of multiple sclerosis patients.” About the Study The multi-national, multi-center, prospective, double-blind, randomized, Phase III insignificant house be conduct in going on uttermost of for 100 centers to be found in the U.S., Europe, Argentina, Israel, Nordic terrain, Australia and New Zealand. It integrated a whole of 481 patients reminder with a individual clinical chunk and MRI signifying MS. Patients included be those who personal a unifocal firebrand manifestation (i.e., clinical substantiation of a single lesion). Patients received any COPAXONE® 20mg/day or placebo as a subcutaneous shot and repeated treatment for conscious to 36 months, unless a second raid was knowing and they were diagnose with CDMS. Patients who converted to CDMS continued the examination on helpful treatment for an extramural two years. The earliest efficacy expiration was juncture to CDMS, base on a second clinical attack.

COPAXONE® (glatiramer acetate injection) was also demonstrated to be astoundingly tolerate in the PreCISe study, with a moment ago 16 percent overall dropout during the able to three-year study period, redolent of that observed in RRMS patients pleasure with COPAXONE®. All patients in the study play a part in a follow-on study with COPAXONE® to prospectively calculate the impact of early versus delayed treatment with COPAXONE® on the long-term module of the disease for a total watch time of up to five years.

A pre-planned period in-between analysis was carry out on follow-up accumulate from approximately 80 percent of the three-year placebo-controlled study revealing. Results of the interim analysis, announced in December 2007, demonstrated the piece of patients surfacing CDMS was reduced from 43 percent in the placebo stomp to only 25 percent in the COPAXONE® group (p< 0.0001). The PreCISe study also demonstrated that the 25th percentile of cipher of days to rendition to CDMS have higher than double by COPAXONE® from 336 days to 722 days (hazard ratio 0.55, p=0.0005) equate with placebo.

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