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TorreyPines Therapeutics, Inc. (Nasdaq: TPTX) today announced the training of a Phase IIb clinical exam surrounded by means of rather of its install products hopeful, tezampanel, a unproved niggle amalgamated in movement for the nurture of acute migraine. An AMPA/kainate (AK) receptor antagonist, tezampanel offer a non-narcotic, non-vascular standpoint to the headship of headache pain and embody a potentially nascent alternative to general migraine treatment.

About Lexicon Genetics Lexicon Genetics is a biopharmaceutical guests settled in opposition discover and nascent breakthrough healing in favour of human bug. Lexicon is correctly discovering the physiological and behavioral function of genes to identify statement point of invigorating negotiation, or drug targets. Lexicon make these discovery using its proprietary gene knockout technology to classic the physiological effects that could be appointed from prospective drugs address these targets. For targets that the company reflect have elevated pharmaceutical convenience, it engage in programs for the acceptance and changeover for the better of mini molecule, antibody and protein drugs. Lexicon has advanced knockout-validated targets into drug discovery programs in six therapeutic region: diabetes and podginess, cardiovascular disease, psychiatric and neurological wildness, cancer, immune set of connections disorders and ophthalmic disease. Lexicon is in working condition both spaced out and through collaboration and strategic alliances to get a move on the development and commercialization of its discoveries.

Safe Harbor Statement This constrict set free encompass “forward-looking avowal,” together with statements relating to Lexicon’s regulatory filings and clinical development program for LX1031 and the potential therapeutic and commercial potential of LX1031 and other potential drug applicant in Lexicon’s preclinical pipeline. This press release also contains forward-looking statements relating to Lexicon’s expansion and projected operating grades, discovery and development of products, strategic alliances and blast principal, by scheme of all right as other matter that be not historical facts or intelligence. All forward-looking statements are base on management’s customary assumption and expectations and require risk, uncertainties and other high-status factor, forcefully including those relating to Lexicon’s nimbleness to exultantly conduct clinical development of LX1031 and preclinical development of other potential drug candidates, finance superfluous candidates into preclinical and clinical development, land vital regulatory approvals, realize its running objectives, obtain exclusive rights sanctuary for its discoveries and root strategic alliances, in addition as additional factors relating to buying, intellectual property rights, and the therapeutic or commercial value of its drug candidates, that may end in Lexicon’s actual results to be materially differing from any future results expressed or implied by such forward-looking statements. Information identify such important factors is contained wool the stairs “Factors Affecting Forward-Looking Statements” and “Business – Risk Factors” in Lexicon’s annual gossip on Form 10-K for the year done December 31, 2005, as record effective the Securities and Exchange Commission. Lexicon buy and sell lacking reproach to update or alter any such forward-looking statements, whether as a consequences of new information, future trial or otherwise.

Lexicon Genetics Incorporated

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